Effects of Glycerol on Cochlear Frequency Selectivity in Patients with Menière's Disease During transtympanic electrocochleography, action potential (AP) tuning curves were derived as a measure of cochlear frequency selectivity. In 18 out of 21 patients with symptoms of Menière's disease, a poor frequency selectivity was observed. In 12 subjects the effects on frequency selectivity of oral glycerol were measured, and in 5 ... Brief Report
Brief Report  |   May 01, 1985
Effects of Glycerol on Cochlear Frequency Selectivity in Patients with Menière's Disease
 
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Article Information
Brief Report   |   May 01, 1985
Effects of Glycerol on Cochlear Frequency Selectivity in Patients with Menière's Disease
Journal of Speech and Hearing Disorders, May 1985, Vol. 50, 213-217. doi:10.1044/jshd.5002.213
History: Received May 25, 1984 , Accepted February 11, 1985
 
Journal of Speech and Hearing Disorders, May 1985, Vol. 50, 213-217. doi:10.1044/jshd.5002.213
History: Received May 25, 1984; Accepted February 11, 1985

During transtympanic electrocochleography, action potential (AP) tuning curves were derived as a measure of cochlear frequency selectivity. In 18 out of 21 patients with symptoms of Menière's disease, a poor frequency selectivity was observed. In 12 subjects the effects on frequency selectivity of oral glycerol were measured, and in 5 patients AP tuning curves indicated an improvement in sharpness of tuning by a factor of 1.5–2.5. These changes started approximately 30 min after oral glycerol administration. In 2 subjects there was a deterioration in AP tuning. In 5 patients no significant changes were observed.

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